Effect of therapeutic hypothermia according to severity of sepsis in a septic rat model

► We examine the effects of the therapeutic hypothermia in sepsis model. ► We used sepsis model with two different severities. ► Therapeutic hypothermia has beneficial effects only in severe model of sepsis. ► The beneficial effects were shown by longer survival rate and less organ injury. ► The effects could be partly explained by anti-inflammatory effects of hypothermia.