Emerging avenues linking inflammation, angiogenesis and Sjögren's syndrome

► The salivary epithelial cells perpetuate chronic inflammation in Sjögren's syndrome. ► Sjögren's syndrome is characterized by the overexpression of inflammatory cytokines. ► Angiogenesis and inflammation are mutually correlated. ► Neovascularization contributes to the perpetuation of inflammation. ► The production of angiogenic factors occurs via NF-κB activation.