Activation profile of CXCL8-stimulated neutrophils and aging

► First description about human neutrophils from elderly individuals exogenous CXCL8. ► CXCL8 activated-neutrophils from elderly individuals did not secrete IL-6. ► CXCL8 or LPS unaffected myeloperoxidase of neutrophils from elderly individuals. ► LPS-activated neutrophils from elderly individuals produced increased IL-10 level. ► LPS and CXCL8-activated neutrophils from aged individuals produced increased GM-CSF.