High plasma levels of soluble ST2 but not its ligand IL-33 is associated with severe forms of pediatric dengue

► Soluble ST2 (sST2) but not its ligand IL-33 is increased in dengue infections. ► Higher levels of sST2 are associated with severe cases of pediatric dengue. ► Plasma sST2 has positive association with other pro-inflammatory cytokines previously described in acute dengue infections. ► A biomarker cytokine sST2 predictor of dengue severity is proposed.