Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic biomarker in the pathogenesis of chronic periodontal disease

► Analyzed MCP-1 levels in GCF, saliva and serum in patients with chronic periodontitis. ► Compared these levels with healthy controls at baseline and after phase I therapy. ► Significantly high levels of MCP-1 seen in all three fluids of diseased patients. ► Marked correlation in levels of MCP-1 seen with increasing severity of disease. ► Significantly less MCP-1 after scaling and concordant levels in all three fluids.