CXCL1 expression in human decidua in vitro is mediated via the MAPK signalling cascade

CXCL1 is a target for the embryos' secretion product IL-1β in decidualised endometrial stromal cells during the peri-implantation period. IL-1β's rapid effect on CXCL1 synthesis is uniquely mediated via the MAPK-signalling cascade and the activation of CXCL1s' transcription factor NFκB p65.