IL-1 and EGF regulate expression of genes important in inflammation and cancer

► Description of PRRs (particularly NLRs), their role in the development of inflammation. ► Biological role of IL-1, activation of NFκB and Elk-1 as a result of IL-1RI activation. ► Mechanisms of EGF action, with particular emphasis of the activation of Elk-1. ► Role of EGFR signaling in cancer development. ► Relationship between inflammation and tumorigenesis.