کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5897911 1155279 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death
چکیده انگلیسی

In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions.

► This review covers the current knowledge on IL-32. ► The role of IL-32 in innate immunity and autoimmune diseases. ► Splicing of IL-32γ functions as a safety switch to prevent secretion and runaway inflammation. ► Induction of cell death by IL-32. ► Novel insights into cell homeostasis; extracellular and intracellular functions of IL-32 in integrin-signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 60, Issue 2, November 2012, Pages 321-327
نویسندگان
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