کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5897911 | 1155279 | 2012 | 7 صفحه PDF | دانلود رایگان |

In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions.
⺠This review covers the current knowledge on IL-32. ⺠The role of IL-32 in innate immunity and autoimmune diseases. ⺠Splicing of IL-32γ functions as a safety switch to prevent secretion and runaway inflammation. ⺠Induction of cell death by IL-32. ⺠Novel insights into cell homeostasis; extracellular and intracellular functions of IL-32 in integrin-signaling.
Journal: Cytokine - Volume 60, Issue 2, November 2012, Pages 321-327