Insulin-like growth factor-I regulates the neonatal immune response in infection and maturation by suppression of IFN-γ

► Influence of IGF-I on functional properties of neonatal immune cells. ► IGF-I suppresses Th1 cytokines IL-2 and IFN-γ. ► IGF-I receptor is upregulated upon stimulation of neonatal lymphocytes. ► DNA binding activity of AP-1 and NFκB was decreased by IGF-I.