Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells

► Oxidative stress and inflammation are related to metabolic diseases. ► There is association between lowering antioxidant enzymes and metabolic diseases. ► The study investigated the genetic influence of SOD2 enzyme on cytokines. ► The less efficient SOD2 genotype (VV) presented higher proinflammatory cytokines. ► The antioxidant metabolism acts on proinflammatory and antiinflammatory cytokines.