Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells

► LPS induces IL-17 and IL-23 expression, and IL-17 secretion. ► LPS increase SIRT1 protein and mRNA levels. ► SIRT1 siRNA and sirtinol blocked LPS-induced IL-17 and IL-23 expression.