IL-5 and IL-17A are critical for the chronic IgE response and differentiation of long-lived antibody-secreting cells in inflamed tissues

► IL-5 and IL-17A influence the maintenance of B1a in the BM. ► IL-5 and IL-17A are crucial for the maintaining of specific-IgE secreting cell functions. ► IL-5 and IL-17A negatively regulates the maintenance of ASC B220pos. ► IL-5 and IL-17A are critical for the maintenance of ASC B220neg in inflamed tissue.