Podocyte injury and overexpression of vascular endothelial growth factor and transforming growth factor-beta 1 in adriamycin-induced nephropathy in rats

► We discuss the podocyte number in ADR-induced nephropathy. ► A reduction in podocyte number results in proteinuria and FSGS. ► We discuss the expression of nephrin, VEGF and TGF-β1 in ADR-induced nephropathy. ► Altered nephrin, VEGF, and TGF-β1 may have a role for the proteinuria and FSGS.