The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway

► This is the first study for a physiological role of CTRP3 in the reproductive system. ► CTRP3 expresses in testicular Leydig cells. ► CTRP3 promotes testosterone production in Leydig cells. ► Effect of CTRP3 on testosterone production is associated with cAMP/PKA pathway.