Amelogenins modulate cytokine expression in LPS-challenged cultured human macrophages

► Amelogenins induce a reduced inflammatory response in cultured LPS-challenged human macrophages. ► Increased secretion of AMAC-1 and VEGF by human macrophages after treatment with amelogenins. ► Suggestive amelogenin-promoted switch of LPS-challenged human macrophage phenotype towards tissue repair in vitro.