Autophagy and cytokines

► Autophagy is differentially regulated by numerous cytokines. ► Th1 cytokines induce autophagy; Th2 cytokines inhibit autophagy. ► Autophagy is an effector of cytokines in the response of macrophages to Mycobacterium tuberculosis. ► Autophagy regulates the secretion of numerous cytokines. ► Autophagy may play an important role in the regulation of inflammation.