TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia

► We observed a positive correlation between IL-18 and Uric Acid. ► Classical markers of prognosis were associated with IL-18 and Uric Acid. ► The inflammasome probably contributes or influences vascular events in SCA. ► We suggest the IL-18 and Uric Acid as important biomarkers in monitoring SCA patients.