Monitoring serum levels ELR+ CXC chemokines and the relationship between microvessel density and angiogenic growth factors in multiple myeloma

► ELR+ motif CXC chemokines (IL-8, ENA-78 and GRO-α) correlate with angiogenic activity in multiple myeloma. ► GRO-α showed a distinct angiogenic profile as well as an important factor of disease activity in multiple myeloma patients. ► Increased serum levels of ELR+ motif CXC chemokines with advanced disease stage.