Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

► Doxycycline inhibits pro-inflammatory cytokines in bacterially-challenged monocytes. ► It also enhances anti-inflammatory cytokines in bacterially-challenged monocytes. ► This property may contribute to the clinically proven benefits of doxycycline.