Cytokine profiles in localized scleroderma and relationship to clinical features

► We reviewed the literature for cytokine profiles in localized scleroderma (LS). ► Though limited in LS, most findings reflect cytokine profiles in systemic sclerosis. ► Both Th1 and Th2 cytokines are found to be elevated in the sera of LS patients. ► Elevated cytokines correlate to clinical data such as LS subtype and disease burden. ► Assessment of disease activity and cytokine profile in the tissue should be considered.