کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5901219 | 1568914 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are the most abundant steroid hormones in primates, providing a large reservoir of precursors for the production of androgens. DHEAS levels decline with age in adult humans and nonhuman primates, prompting its consideration as a biomarker of senescence. However, the mechanisms responsible for this age-related decrease and its relationship to reproduction remain elusive. This research investigated DHEAS concentrations in fecal samples in order to determine age-related changes in captive Japanese macaques, as well as to assess the possible influence of seasonality. The subjects were 25 female Japanese macaques (2Â weeks to 14Â years-old) housed outdoors in social groups at the Primate Research Institute. We collected three fecal samples from each animal during the breeding season (October to December) and three additional samples from adult females during the non-breeding season (May to June). The hormonal concentrations were determined using enzyme immunoassay. DHEAS concentration was negatively correlated with age, but we did not find a significant difference between breeding and non-breeding seasons. Neonatal macaques had the highest DHEAS concentrations of all age groups. We suggest that elevated neonatal DHEAS is possibly a residue from fetal adrenal secretion and that, as in humans, it might assist in neurobiological development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 191, 15 September 2013, Pages 39-43
Journal: General and Comparative Endocrinology - Volume 191, 15 September 2013, Pages 39-43
نویسندگان
Rafaela Sayuri Cicalise Takeshita, Michael A. Huffman, Fred B. Bercovitch, Keiko Mouri, Keiko Shimizu,