کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5902448 1156851 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benefits of timely basal insulin control in patients with type 2 diabetes
ترجمه فارسی عنوان
مزایای کنترل زمان انسولین بازال در بیماران مبتلا به دیابت نوع 2
کلمات کلیدی
درمان انسولین، اهداف گلیسمی، تیتراسیون انسولین، انسولین پایه، شروع انسولین، دیابت نوع 2،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Worldwide, both underdiagnosis and undertreatment leave many patients exposed to long periods of hyperglycemia and contribute to irreversible diabetes complications. Early glucose control reduces the risk of both macrovascular and microvascular complications, while tight control late in diabetes has little or no macrovascular benefit. Insulin therapy offers the most potent antihyperglycemic effect of all diabetes agents, and has a unique ability to induce diabetes remission when used to normalize glycemia in newly diagnosed patients. When used as a second-line therapy, basal insulin is more likely to safely and durably maintain A1C levels ≤ 7% than when insulin treatment is delayed. The use of basal insulin analogs is associated with a reduced risk of hypoglycemia and weight gain compared to NPH insulin and pre-mixed insulin. Patient self-titration algorithms can improve glucose control while decreasing the burden on office staff. Finally, recent data suggest that addition of incretin agents to basal insulin may improve glycemic control with very little, if any increased risk of hypoglycemia or weight gain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 29, Issue 2, March 2015, Pages 295-301
نویسندگان
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