کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905086 | 1159829 | 2016 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Common and differentially expressed long noncoding RNAs for the characterization of high and low grade bladder cancer
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کلمات کلیدی
EZH2(GO)(FC)Long non-coding RNAs - RNA های بدون کدگذاری طولانیSearch Tool for the Retrieval of Interacting Genes - ابزار جستجو برای بازیابی ژن های تعاملFunctional enrichment analysis - تجزیه و تحلیل غنی سازی عملکردیProtein-protein interaction - تعامل پروتئین-پروتئینfold change - تغییر در برابرBladder cancer - سرطان مثانهurothelial carcinoma - سرطان پروستاتMALAT1 - مالتا 1Gene ontology - هستیشناسی ژنیGene Expression Omnibus - ژن بیان OmnibusDifferentially expressed genes - ژن های متفاوت بیان شده است
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Common and differentially expressed long noncoding RNAs for the characterization of high and low grade bladder cancer Common and differentially expressed long noncoding RNAs for the characterization of high and low grade bladder cancer](/preview/png/5905086.png)
چکیده انگلیسی
Our study aimed to explore long non-coding RNAs (lncRNAs) contributing to the development of bladder cancer, as well as to identify more critical DEGs and lncRNAs that would characterize low- and high-grade bladder cancer. The microarray data of GSE55433 was downloaded from Gene Expression Omnibus database, including 57 urothelial cancer samples (23 low-grade NMI, 14 high-grade NMI and 20 invasive tumors) and 26 normal controls. The differentially expressed genes (DEGs) and differentially expressed lncRNAs were identified in 3 groups (low-grade NMI vs. normal, high-grade NMI vs. normal and invasive UC vs. normal). Functional enrichment analysis was performed upon the DEGs in different groups. Besides, protein-protein interaction (PPI) network was constructed based on common DEGs and remaining DEGs in each group. Co-expression analysis was performed to identify the co-expressed DEG-lncRNAs pairs. Different number of DEGs and differentially expressed lncRNAs were respectively identified from those 3 groups. NONHSAG013805 (down-regulated) and NONHSAG009271 (down-regulated) were common lncRNAs. NONHSAG013805 was connected with the down-regulated gene EIF3E and NONHSAG009271 was linked to MYL12A (down-regulated). Moreover, NONHSAG034203 (up-regulated) was co-expressed with ADM5 (up-regulated) in low-grade NMI cancer, while the down-regulated NONHSAG045391 was connected with the down-regulated DEGs DAD1 and STUB1 in high-grade NMI cancer and invasive bladder cancer. Our study indicates that NONHSAG013805 and NONHSAG009271 may play key roles in bladder cancer via co-expressing with EIF3E and MYL12A, respectively. Moreover, NONHSAG034203 may be involved in low-grade NMI bladder cancer via targeting ADM5, while NONHSAG045391 may contribute to high-grade NMI and invasive bladder cancer via targeting DAD1 and STUB1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 592, Issue 1, 30 October 2016, Pages 78-85
Journal: Gene - Volume 592, Issue 1, 30 October 2016, Pages 78-85
نویسندگان
Miao Wang, Xingyuan Xiao, Fuqing Zeng, Fei Xie, Yebin Fan, Chao Huang, Guosong Jiang, Liang Wang,