کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5905192 1159857 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
ReviewTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships
چکیده انگلیسی


- Higher vertebrate genomes contain three troponin I genes, TNNI1, TNNI2 and TNNI3.
- The muscle fiber type-specific troponin I isoforms are evolutionarily diverged.
- Each of the isoform genes is conserved across species.
- The N-terminal extension of cardiac troponin I is an adult heart-specific regulator.
- Mutations of troponin I cause myopathies.

Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation. Vertebrate TnI has evolved into three isoforms encoded by three homologous genes: TNNI1 for slow skeletal muscle TnI, TNNI2 for fast skeletal muscle TnI and TNNI3 for cardiac TnI, which are expressed under muscle type-specific and developmental regulations. To summarize the current knowledge on the TnI isoform genes and products, this review focuses on the evolution, gene regulation, posttranslational modifications, and structure-function relationship of TnI isoform proteins. Their physiological and medical significances are also discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 576, Issue 1, Part 3, 15 January 2016, Pages 385-394
نویسندگان
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