کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905420 | 1159886 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral expression of hepcidin gene in Egyptian β-thalassemia major
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کلمات کلیدی
MCVBmp6ALTqRT-PCRcDNA - cDNAComplementary DNA - DNA تکمیلیβ-thalassemia - β-تالاسمیaspartate aminotransferases - آسپارتات آمینوترانسفرازAST - آسپارتات ترانس آمینازalanine aminotransferases - آلانین آمینوترانسفرازهاmicroparticle enzyme immunoassay - آنزیم میکروپروسسیم ایمنیErythroferrone - اریتروفررونMEIA - بقیهMean corpuscular volume - حجم متوسط مایعquantitative real time PCR - زمان واقعی PCR کمیmilliseconds - میلی ثانیهHemoglobin - هموگلوبینHepatitis C virus - هپاتیت سیHCV - هپاتیت سیBone morphogenetic protein 6 - پروتئین مورفوژنیک استخوان 6
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Iron overload is the major cause of morbidity and mortality in transfusion dependent β-thalassemia major patients. There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin. Hepcidin is the main iron regulatory molecule; it is secreted mainly by the liver and other tissues including monocytes and lymphocytes. Expression of hepcidin in such cells is unclear and has been studied in few reports with controverted result. Peripheral expression of hepcidin was measured using quantitative real time PCR (qRT-PCR) in 50 β-thalassemia major patients, in addition to 20 healthy volunteers as a control group. Hepcidin levels in β-thalassemia major patients showed statistically significant decrease in comparison to the control group, and was correlated to cardiac iron stores (T2*). However, hepcidin level was not different among the patients according to the HCV status or whether splenectomized or not. In conclusion; peripheral expression of hepcidin, in iron overloaded β-thalassemia major patients, is a reflection of hepatic expression. It can be used as a molecular predictor for the severity of cardiac iron overload and can be used as a future target for therapy in β-thalassemia major patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 564, Issue 2, 15 June 2015, Pages 206-209
Journal: Gene - Volume 564, Issue 2, 15 June 2015, Pages 206-209
نویسندگان
Azza Aboul-Enein, Amal EL-Beshlawy, Mona Hamdy, Iman Shaheen, Zainab El-Saadany, Ahmed Samir, Hala Abd El-Samie,