کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905555 | 1159908 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of the rank-based method to DNA methylation for cancer diagnosis
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کلمات کلیدی
STADCOADGEOBRCATSPKNNTCGAk-nearest neighbor - K نزدیکترین همسایهstomach adenocarcinoma - آدنوکارسینوم معدهColon adenocarcinoma - آدنوکارسینوم کولونThe cancer genome atlas - اوتومتر ژنوم سرطانcancer diagnosis - تشخیص سرطانlung adenocarcinoma - سرطان ریهLUAD - لویدSVM - ماشین بردار پشتیبانیSupport vector machine - ماشین بردار پشتیبانیDNA methylation - متیلاسیون DNAGene Expression Omnibus - ژن بیان OmnibusLung squamous cell carcinoma - کارسینوم سلول سنگفرشی ریهLUSC - یک چشم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Application of the rank-based method to DNA methylation for cancer diagnosis Application of the rank-based method to DNA methylation for cancer diagnosis](/preview/png/5905555.png)
چکیده انگلیسی
Detecting aberrant DNA methylation as diagnostic or prognostic biomarkers for cancer has been a topic of considerable interest recently. However, current classifiers based on absolute methylation values detected from a cohort of samples are typically difficult to be transferable to other cohorts of samples. Here, focusing on relative methylation levels, we employed a modified rank-based method to extract reversal pairs of CpG sites whose relative methylation level orderings differ between disease samples and normal controls for cancer diagnosis. The reversal pairs identified for five cancer types respectively show excellent prediction performance with the accuracy above 95%. Furthermore, when evaluating the reversal pairs identified for one cancer type in an independent cohorts of samples, we found that they could distinguish different subtypes of this cancer or different malignant stages including early stage of this cancer from normal controls. The identified reversal pairs also appear to be specific to cancer type. In conclusion, the reversal pairs detected by the rank-based method could be used for accurate cancer diagnosis, which are transferable to independent cohorts of samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 555, Issue 2, 25 January 2015, Pages 203-207
Journal: Gene - Volume 555, Issue 2, 25 January 2015, Pages 203-207
نویسندگان
Hongdong Li, Guini Hong, Hui Xu, Zheng Guo,