کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905620 | 1159909 | 2015 | 7 صفحه PDF | دانلود رایگان |
- We showed that microRNAs have unique signatures that distinguish breast cancer subtypes.
- It is also found that new breast cancer subtypes, other than the four known, might exist.
- We identified microRNA biomarkers specific to breast cancer subtypes.
MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development. Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim.
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Journal: Gene - Volume 556, Issue 2, 10 February 2015, Pages 192-198