کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5906202 1159963 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewSonoporation: Mechanistic insights and ongoing challenges for gene transfer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
ReviewSonoporation: Mechanistic insights and ongoing challenges for gene transfer
چکیده انگلیسی


- sonoporation, a promising physical method for gene delivery
- interactions of microbubbles with cells by high speed imaging
- intracellular fate of cargo after sonoporation
- microbubble features for gene delivery by sonoporation

Microbubbles first developed as ultrasound contrast agents have been used to assist ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound exposure leads to transient membrane permeability of surrounding cells, facilitating targeted local delivery. The increased cell uptake of extracellular compounds by ultrasound in the presence of microbubbles is attributed to a phenomenon called sonoporation. In this review, we summarize current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery. Optimization of sonoporation protocol and composition of microbubbles for gene delivery are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 525, Issue 2, 10 August 2013, Pages 191-199
نویسندگان
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