کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5906534 | 1159973 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CC chemokine receptor-3 as new target for age-related macular degeneration
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کلمات کلیدی
CNVSDSCCR3SNPsVEGF-AFFACECAMDMCP1GPCRRPEG-protein-coupled receptor - G-پروتئین گیرندهChoroidal neovascularization - neovascularization choroidalfluorescein fundus angiography - آنژیوگرافی فوندوس فلورسینinflammation - التهاب( توروم) retinal pigment epithelium - اپیتلیوم رنگدانه شبکیهOct - اکتبرOptical coherence tomography - توموگرافی انسجام نوریage-related macular degeneration - سن تخریب ماکولا مربوط به سن استvascular endothelial growth factor-A - فاکتور رشد اندوتلیال عروق APopulation study - مطالعه جمعیتmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1Single nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیChemokines - کرموین ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
CC chemokine receptor-3 (CCR3) is involved in angiogenic processes. Recently, CCR3 was accounted to participate in choroidal neovascularization (CNV) and CCR3 targeting was reported to be superior to standard antivascular endothelial growth factor-A (VEGF-A) administration when tested in an artificially induced CNV in animals. As human CCR3 studies are lacking in age-related macular degeneration (AMD) patients we sought to determine if CCR3 has any association with inflammatory processes that occur in CNV. A total of 176 subjects were included on the basis of inclusion criteria. Real time PCR was used to analyze the single nucleotide polymorphism in CCR3 of AMD (115) and normal controls (n = 61). Genotype frequency was adjusted for possible confounders like cigarette smoking, alcohol, meat consumption and other risk factors. Chi-square test was used for analysis of polymorphism. The genotype distribution of CCR3 (rs3091250) polymorphism was significantly different in AMD patients in the Indian population. GT (heterozygous) and TT (homozygous) at the rs3091250 SNP increased risk of AMD as compared to the GG genotypes (OR = 4.8, CI 95% = 2.2-10.8 and OR = 4.1, CI 95% = 1.6-10.1 respectively). Subgroup analysis of AMD patients in wet and dry revealed no significant differences. There was no significant difference for rs3091312 in AMD and control group. A significant association between AMD and CCR3 (rs3091250) polymorphism localized on chromosome 3p21.3 was detected. The results suggest the possible contribution of rs3091250, a new predisposing allele in AMD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 523, Issue 1, 1 July 2013, Pages 106-111
Journal: Gene - Volume 523, Issue 1, 1 July 2013, Pages 106-111
نویسندگان
Neel Kamal Sharma, Amod Gupta, Sudesh Prabhakar, Ramandeep Singh, Arvind Kumar Bhatt, Akshay Anand,