PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele

► LOH of PTCH1 region was detected in 27.3% OC, 18.2% OF and 55.6% OD samples. ► No point mutations were detected in any of the three types of ovarian tumors. ► Significant differences were found for SNP c.3944C>T between OC and control samples. ► New c.−1184G>A polymorphism was found only in tumor samples.