Screening and comparison of differentially expressed genes between one MDR-TB strain and the virulent M. tuberculosis H37Rv

► The gene expression between MDR-TB and drug-sensitive TB were different. ► The genes expressed in the MDR-TB but not in the H37Rv were selected. ► Suppression subtractive hybridization (SSH) technology was used in the study. ► 113 positive clones were obtained and four novel sequences were identified. ► Identification of these genes may help to understanding of MDR-TB development.