Surface chemistry of porous silicon and implications for drug encapsulation and delivery applications

► Porous silicon (pSi) has significant potential as a drug delivery vehicle. ► The hydride terminated surface can be passivated via oxidation and hydrosilylation. ► Surface modification can be used to tailor drug-pSi interactions. ► By controlling drug crystallinity within pSi pores, drug dissolution is enhanced. ► Techniques such as XPS and ToF-SIMS provide insight into modification and loading.