کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
591153 1453601 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyelectrolyte-coated liposomes: Stabilization of the interfacial complexes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Polyelectrolyte-coated liposomes: Stabilization of the interfacial complexes
چکیده انگلیسی

Anionic liposomes, composed of egg lecithin (EL) or dipalmitoylphosphatidylcholine (DPPC) with 20 mol% of cardiolipin (CL2−), were mixed with cationic polymers, poly(4-vinylpyridine) fully quaternized with ethyl bromide (P2) or poly-l-lysine (PL). Polymer/liposome binding studies were carried out using electrophoretic mobility (EPM), fluorescence, and conductometry as the main analytical tools. Binding was also examined in the presence of added salt and polyacrylic acid (PAA). The following generalizations arose from the experiments: (a) Binding of P2 and PL to small EL/CL2− liposomes (60–80 nm in diameter) is electrostatic in nature and completely reversed by addition of salt or PAA. (b) Binding can be enhanced by hydrophobization of the polymer with cetyl groups. (c) Binding can also be enhanced by changing the phase state of the lipid bilayer from liquid to solid (i.e. going from EL to DPPC) or by increasing the size of the liposomes (i.e. going from 60–80 to 300 nm). By far the most promising systems, from the point of view of constructing polyelectrolyte multilayers on liposome cores without disruption of liposome integrity, involve small, liquid, anionic liposomes coated initially with polycations carrying pendant alkyl groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Colloid and Interface Science - Volume 142, Issues 1–2, 1 October 2008, Pages 43–52
نویسندگان
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