Preparation of oligosaccharide surfactant based on cotton cellulose and application in hydrophilic modification of docetaxel

• Soluble oligosaccharide with a narrow molecular weight distribution was prepared successfully.
• Oligosaccharide–polypropylene oxide surfactant was synthesized by ring-opening reaction.
• Oligosaccharide–polypropylene oxide surfactant showed fine surface active.
• Oligosaccharide–polypropylene oxide surfactant could be used to load docetaxel.

This paper presented a novel and effective route to prepare oligosaccharide–polypropylene oxide (PPO) surfactant and use thereof to synthesize graft copolymer oligosaccharide–PPO–docetaxel (DTX). The products were characterized by GPC, FTIR and 1H NMR. Surface tensions of oligosaccharide–PPO surfactants had been investigated using the Du Noüy and steady-state fluorescence methods. The results revealed that the degree of polymerization of the soluble oligosaccharide, which was tailored from cotton cellulose in phosphoric acid medium, was equal to 7; the oligosaccharide–PPO surfactant possessed good surface activity while the adduct number of propylene oxide reached to 20; the DTX was completely dispersed in water medium with oligosaccharide–PPO–DTX micelle and the drug-loading rate reached 32.6%, which showed great potential for clinical application and was worthy of further research.

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