کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5914223 | 1162725 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures](/preview/png/5914223.png)
چکیده انگلیسی
The recently discovered HEAT-like repeat (HLR) DNA glycosylase superfamily is widely distributed in all domains of life. The present bioinformatics and phylogenetic analysis shows that HLR DNA glycosylase superfamily members in the genus Bacillus form three subfamilies: AlkC, AlkD and AlkF/AlkG. The crystal structure of AlkF shows structural similarity with the DNA glycosylases AlkC and AlkD, however neither AlkF nor AlkG display any DNA glycosylase activity. Instead, both proteins have affinity to branched DNA structures such as three-way and Holliday junctions. A unique β-hairpin in the AlkF/AlkG subfamily is most likely inserted into the DNA major groove, and could be a structural determinant regulating DNA substrate affinity. We conclude that AlkF and AlkG represent a new family of HLR proteins with affinity for branched DNA structures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 183, Issue 1, July 2013, Pages 66-75
Journal: Journal of Structural Biology - Volume 183, Issue 1, July 2013, Pages 66-75
نویسندگان
Paul H. Backe, Roger Simm, Jon K. Laerdahl, Bjørn Dalhus, Annette Fagerlund, Ole A. Ãkstad, Torbjørn Rognes, Ingrun Alseth, Anne-Brit Kolstø, Magnar BjørÃ¥s,