کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5914596 1162746 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex
چکیده انگلیسی
Interestingly, truncation of domain II led to a substantial increase in ATP consumption of RuvBL1, RuvBL2 and their complex. In addition, we present evidence that DNA unwinding of the human RuvBL proteins can be auto-inhibited by domain II, which is not present in the homologous bacterial helicase RuvB. Our data give new insights into the molecular arrangement of RuvBL1 and RuvBL2 and strongly suggest that in vivo activities of these highly interesting therapeutic drug targets are regulated by cofactors inducing conformational changes via domain II in order to modulate the enzyme complex into its active state.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 176, Issue 3, December 2011, Pages 279-291
نویسندگان
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