The Plasmodium protein P113 supports efficient sporozoite to liver stage conversion in vivo

- Systematic genetic characterization of P. berghei membrane lipid raft ortholog P113.
- Pre-erythrocytic expression control of P113 shows key signatures of UIS genes.
- Ablation of P113 is compatible with successful Plasmodium life cycle progression.
- p113(−) parasites are impaired in sporozoite to liver stage conversion in vivo.
- P113 is a ubiquitous but dispensable protein of malarial parasites.