Cryptosporidium parvum has an active hypusine biosynthesis pathway

- Cryptosporidium parvum has an active hypusine biosynthetic pathway.
- Unique modifications occur on translational elongation factor, eIF5A.
- It has single copy of deoxyhypusine synthase (DHS) unlike kinetoplastids.
- Km of CpDHS for eIF5A was higher than that of the human.
- Diamines and N-guanyl diamines inhibited C. parvum growth.