Ca2+-activated transbilayer movement of plasma membrane phospholipids in Leishmania donovani during ionomycin or thapsigargin stimulation

► Ionomycin and thapsigargin elevate intracellular Ca2+ in Leishmania donovani. ► Increase in cytosolic Ca2+ triggers loss of plasma membrane lipid asymmetry. ► Increase in cytosolic Ca2+ induces transbilayer redistribution of fluorescent lipids. ► Ca2+ release from intracellular compartments alone can trigger lipid redistribution.