An atypical proprotein convertase in Giardia lamblia differentiation

▶ Defined the Giardia lamblia degradome. ▶ Identified a novel putative subtilisin-like proprotein convertase. ▶ Show traffic of a serine protease in the encystation pathway. ▶ Show that a serine protease inhibitor blocks Giardia differentiation, not growth. ▶ Serine proteases are important in the lifecycle of Giardia.