کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5915996 1570659 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The RhopH complex is transferred to the host cell cytoplasm following red blood cell invasion by Plasmodium falciparum
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
The RhopH complex is transferred to the host cell cytoplasm following red blood cell invasion by Plasmodium falciparum
چکیده انگلیسی
The high-molecular mass rhoptry protein complex (PfRhopH), which comprises three distinct gene products, RhopH1, RhopH2, and RhopH3, is known to be secreted and transferred to the parasitophorous vacuole membrane upon invasion of a red blood cell by the malaria parasite Plasmodium falciparum. Here we show that the merozoite-acquired RhopH complex is also transferred to defined domains of the red blood cell cytoplasm, and possibly transiently associated with Maurer's clefts. This is the first report of trafficking in the host cell cytoplasm for P. falciparum rhoptry proteins secreted upon red blood cell invasion. Based on its newly identified sub-cellular location and the phenotype of RhopH1 mutants, we propose that the RhopH complex participate in the assembly of the cytoadherence complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 160, Issue 2, August 2008, Pages 81-89
نویسندگان
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