کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916189 | 1163370 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ReviewS-Adenosylmethionine in protozoan parasites: Functions, synthesis and regulation ReviewS-Adenosylmethionine in protozoan parasites: Functions, synthesis and regulation](/preview/png/5916189.png)
S-adenosylmethionine is one of the most frequently used enzymatic substrates in all living organisms. It plays a role in all biological methyl transfer reactions in as much as it is a donor of propylamine groups in the synthesis of the polyamines spermidine and spermine, it participates in the trans-sulphuration pathway to cysteine one of the three amino acids involved in glutathione and trypanothione synthesis in trypanosomatids and finally it is a source of the 5-deoxyadenosyl radicals, which are involved in many reductive metabolic processes, biodegradative pathways, tRNA modification and DNA repair. This mini-review is an update of the progress on the S-adenosylmethionine synthesis in different representative protozoan parasites responsible for many of the most devastating so-called tropical diseases that have an enormous impact on global health.
Journal: Molecular and Biochemical Parasitology - Volume 152, Issue 1, March 2007, Pages 1-10