کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916402 | 1163742 | 2015 | 4 صفحه PDF | دانلود رایگان |
- The ubiquitin-like modifier FAT10 targets proteins for MHC-I presentation.
- There is evidence that FAT10 might be involved in MHC-II antigen presentation.
- FAT10 plays a role in antimicrobial defense against intracellular pathogens.
The ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus, is up-regulated during dendritic cell maturation, is highly expressed in lymphoid tissues, and strongly induced by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. FAT10 is the only ULM known to date which directly targets its hundreds of substrates for degradation by the proteasome. This implies a role for FAT10 in antigen presentation. Indeed, fusion of FAT10 to viral proteins enhanced their presentation along the proteasome dependent MHC class I presentation pathway. In this review we discuss the FAT10 conjugation system as an alternative and distinct pathway for MHC class I and II antigen processing. Furthermore, we review the recent finding that FAT10 plays a role in antimicrobial defense against intracellular pathogens.
Journal: Molecular Immunology - Volume 68, Issue 2, Part A, December 2015, Pages 129-132