کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916743 | 1163755 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The immunology of the porcine skin and its value as a model for human skin
ترجمه فارسی عنوان
ایمنی پوست و ارزش آن به عنوان یک مدل برای پوست انسان
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
پوست گوشت خوک، مدل حیوانی، اپیدرم درم، سلولهای دندریتیک، لنفوسیت ها،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
چکیده انگلیسی
The porcine skin has striking similarities to the human skin in terms of general structure, thickness, hair follicle content, pigmentation, collagen and lipid composition. This has been the basis for numerous studies using the pig as a model for wound healing, transdermal delivery, dermal toxicology, radiation and UVB effects. Considering that the skin also represents an immune organ of utmost importance for health, immune cells present in the skin of the pig will be reviewed. The focus of this review is on dendritic cells, which play a central role in the skin immune system as they serve as sentinels in the skin, which offers a large surface area exposed to the environment. Based on a literature review and original data we propose a classification of porcine dendritic cell subsets in the skin corresponding to the subsets described in the human skin. The equivalent of the human CD141+ DC subset is CD1aâCD4âCD172aâCADM1high, that of the CD1c+ subset is CD1a+CD4âCD172a+CADM1+/low, and porcine plasmacytoid dendritic cells are CD1aâCD4+CD172a+CADM1â. CD209 and CD14 could represent markers of inflammatory monocyte-derived cells, either dendritic cells or macrophages. Future studies for example using transriptomic analysis of sorted populations are required to confirm the identity of these cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 66, Issue 1, July 2015, Pages 14-21
Journal: Molecular Immunology - Volume 66, Issue 1, July 2015, Pages 14-21
نویسندگان
Artur Summerfield, François Meurens, Meret E. Ricklin,