کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916883 | 1163761 | 2014 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ReviewCellular targets of regulatory B cell-mediated suppression ReviewCellular targets of regulatory B cell-mediated suppression](/preview/png/5916883.png)
- Regulatory B cells suppress a wide-variety of inflammatory cells.
- In this review we describe the targets of regulatory B cell-mediated suppression.
- Suppression by regulatory B cells may be cognate, cell-contact-mediated, bystander or indirect.
Regulatory B cells (Bregs) are defined by their ability to restrain inflammatory responses both in vivo and in vitro. Interleukin 10 (IL-10) production by Bregs is thought to be central to their ability to regulate inflammation, largely due to IL-10s' ability to suppress pro-inflammatory cytokine production by effector lymphocytes and to maintain the differentiation of regulatory T cells (Tregs). However, with an increase in available published data, it has become evident that Bregs utilize a number of suppressive mechanisms in order to alter the activation of a variety of different lymphocytes. Here, we summarize the multiplicity of cellular targets of Breg-mediated suppression and describe the mechanisms employed by Bregs to suppress chronic inflammatory responses.
Journal: Molecular Immunology - Volume 62, Issue 2, December 2014, Pages 296-304