Importance of TAP-independent processing pathways

► A subset of MHC-I peptides is generated by alternative processing routes, independent of proteasome and TAP. ► A broad and unique peptide repertoire is presented on TAP-deficient cells. ► Several processing pathways deliver these TAP-independent peptides. ► We are unraveling a novel route that depends on membrane-associated proteolysis and macro-authophagy.