Activation of adjuvant core response genes by the novel adjuvant PCEP

► PCEP is a strong modulator of “adjuvant core response genes” at the site of injection. ► PCEP activates early innate immune responses at the site of injection, which may involve activation of the inflammasome. ► PCEP induces local immuno-stimulatory environment at the site of injection, characterized by production of cytokines and chemokines.