کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5917416 1163792 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An afucosylated anti-CD20 monoclonal antibody with greater antibody-dependent cellular cytotoxicity and B-cell depletion and lower complement-dependent cytotoxicity than rituximab
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
An afucosylated anti-CD20 monoclonal antibody with greater antibody-dependent cellular cytotoxicity and B-cell depletion and lower complement-dependent cytotoxicity than rituximab
چکیده انگلیسی
► Afucosylated rituximab expressed in Lemna was composed of a single major N-glycan species (GnGn) without detectable fucose or xylose. ► Target cell binding and apoptosis induction were similar between the afucosylated rituximab and rituximab. ► Antibody-dependent cellular cytotoxicity (ADCC) and B-cell depletion was increased by the afucosylated rituximab. ► Complement-dependent cytotoxicity (CDC) was attenuated by the afucosylated rituximab. ► The higher ADCC and B-cell depletion suggest a potential improvement in efficacy and potency, while lower CDC may mitigate infusion toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 50, Issue 3, March 2012, Pages 134-141
نویسندگان
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