Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung

► The early pulmonary response to migrating lung schistosomula is characteristic of innate inflammation and wound healing. ► This response is associated with significant up-regulation of chemokine genes that direct cell recruitment. ► This response is associated with significant up-regulation of several genes with immunoregulatory function, including Ch25h, Hmox1 and Retnla. ► This knowledge contributes to our understanding of host-parasite interactions associated with schistosome infection and may aid the future design of novel vaccines that target the lung stage schistosomula.