کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5917667 1163798 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ficolins and FIBCD1: Soluble and membrane bound pattern recognition molecules with acetyl group selectivity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Ficolins and FIBCD1: Soluble and membrane bound pattern recognition molecules with acetyl group selectivity
چکیده انگلیسی
A network of molecules, which recognizes pathogens, work together to establish a quick and efficient immune response to infectious agents. Molecules containing a fibrinogen related domain in invertebrates and vertebrates have been implicated in immune responses against pathogens, and characterized as pattern recognition molecules. Ficolins are soluble oligomeric proteins composed of trimeric collagen-like regions linked to fibrinogen-related domains (FReDs) that have the ability to sense molecular patterns on both pathogens and apoptotic cell surfaces and activate the complement system. The ficolins have acetyl-binding properties, which have been localized to different binding sites in the FReD-region. A newly discovered tetrameric transmembrane protein, FIBCD1, likewise binds acetylated structures via the highly conserved FReD. This review presents current knowledge on acetyl binding FReD-containing molecules, and discusses structural resemblance but also diversity in recognition of acetylated ligands.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 48, Issue 4, January 2011, Pages 369-381
نویسندگان
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